• Topical analgesics work locally without producing significant systemic drug concentrations.
• Their mode of action involves reduction in peripheral sensitization, but central sensitization may also be affected.
• They have a better side-effect profile compared to similar agents given systemically due to less absorption.
• The most commonly prescribed agents are preparations of capsaicin, lidocaine alone or as a mixture with other agents, and nonsteroidal anti-inflammatory agents formulated as cream, paste, gel, patch, or spray
• Evidence from clinical trials suggests that there is a role for the use of certain topical analgesics in the management of neuropathic pain.
• New topical analgesics are currently being developed for both neuropathic as well as other painful conditions.
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Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?