Local anesthetic agents

While other mechanisms of action are being investigated, such as the role of reduced peripheral nociception on the dampening of central pain mechanisms, the analgesic action of local anesthetic agents based upon currently available evidence appears to be related to the ability of these agents to suppress the activity of peripheral sodium channels within the sensory afferents and subsequent pain transmission. They also cause a reduction in paroxysmal ectopic activity in these nerve fibers. Reduced expression of mRNA for specific sodium channel subtypes following local anesthetic use has also been reported.1[III], 4[III]

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