Mechanical stimuli

Von Frey hairs and blunt pressure are the standard tools for mechanical testing in the experimental laboratory. Von Frey hairs bend at different forces, permitting both a stimulus-dependent (threshold to detection and threshold to pain perception) and a response-dependent (evoked sensation to a particular stimulus) pain assessment. This can be performed for single and for repetitive pinprick stimuli. For a dynamic brush, camel hair paintbrushes can be used.

Determination of the area of abnormality may also be a useful outcome measure because such an area of cutaneous abnormality probably reflects the expansion of receptive fields of sensitized dorsal horn neurons.1, 30

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