Other Agents Capsaicin

Capsaicin is the active constituent of hot chilli peppers, responsible for eliciting the symptoms of heat, burning, and erythema. Capsaicin is a potent activator of the TRPV1 receptor, which is also activated by noxious heat above 43°C.101 Capsaicin has been advocated as a topical agent for the therapy of PHN and painful DPN.44[III], 102 [III], 103,104[II], 105[II] The underlying mechanisms may include depletion of substance P via activation of the TRPV1 receptor or desensitization of nerve terminals. The degeneration of epidermal nerve fibers, which is reversible on discontinuing capsaicin, is also postulated to contribute to analgesia.106 The burning induced by cap-saicin can be significantly reduced by pretreatment with a topical anesthetic.107[III] Recently, capsaicin was shown in a preliminary study to relieve intractable neuropathic pain when used in very high doses (5-10 percent) in association with regional anesthesia.108[III] High concentrations of capsaicin (8 percent) applied as a patch for 60 minutes have been shown to mimic the degeneration of epidermal nerve fibers seen with prolonged exposure to low-dose capsaicin and may provide an alternative treatment for neuropathic pain.109[III]

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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