Pathophysiology

Acute injury or disease may cause the pain and nervous system sensitization and this often resolves after healing of the tissue. Such pain and hypersensitivity may persist past resolution of the underlying cause, becomes a self-sustained condition independent of the original pathology that initiated it and becomes in itself a disease entity; a chronic pain.5 Irrespective of the cause of the pain it is associated with negative affect and psychological distress that has been recognized in many pain syndromes of organic origin and of uncertain causes.4 Although the underlying pathophysiology of unexplained pain in which the nociceptive substrate is difficult to find, and enhanced sensitivity to pain are incompletely understood, mechanism-based research suggests a biological plausibility of a common denominator of neural plasticity at different levels of integration that may be important to understand the interplay of body and mind in chronic pain conditions.6

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