To justify the safety of therapy

Some treatments may have inevitable risks. For example, the use of large doses of methadone in patients who have had problems with other opioid analgesics might be questioned in terms of safety or effectiveness. A detailed study has demonstrated that the technique can be used safely and that there are substantial benefits in terms of pain control, return to work, and global quality of life with a relatively low rate of drug diversion, side effects, or complications.9 Again the very wide range of outcome measures that must accompany the assessment of pain is demonstrated. It is very important to note also that outcome is specific to the study and not the technique or drug - methadone can still be lethal if its use is not properly supervised.

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