■ Iatrogenic cause (related to surgery)

■ Vascular disease (Nicholson, 2004)

Brain-related central pain can be caused by events such as stroke. In stroke, the brain receives an insult, such as a clot or an infarct, that causes brain tissue death and tissue swelling. Of the 700,000 Americans who experience stroke, about 8% of the patients develop central-poststroke pain (CPSP). This centrally mediated pain syndrome can present differently in patients affected by the condition. Some patients complain of a burning sensation, whereas others complain of allodynia.

Exhibit 17.1

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