Relative potency 1:6 with acute dosing and 1:2 to 1:3 with chronic dosing

Extended half life with short-acting oral form

Use with caution: Half life of 12-150 hours accumulates with repeated dosing Use with caution. Toxic metabolite normerperidine can cause seizures

Controlled Release


Brand Name

Oral dose

Not recommended for opioid naïve patients


Oxycodone Fentanyl transdermal

MSContin, Avinza, Kadian Oxycontin Duragesic

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