Po

Leukopenia, sulfa hypersensitivity

CBC, platelets q 2-4 wk for 3 mos then CBC q 3 mos

methotrexate

7.5—25 mg/wk

PO, IM, SQ

Bone marrow suppression, pneumonitis, hepatoxicity

CBC, platelets, aspartate aminotransferase, albumin, and albumin q 4—8 wks

leflunomide

10-20 mg/day after 100 mg/day for 3 days as a loading dose

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