NFkB and Immune Function

NFkB activation regulates a certain number of genes which are required for physiological T-cell response. These include IL-2, IL-6, IL-8 genes as well as a number of receptor genes (Fig. 5.1). There is evidence that the intracellular redox condition is a very important regulator of NFkB function. ROS have been denoted as universal second messengers of the T-cell signalling cascade, which can activate NFkB [46,93-95]. However, oxidation is unable to fully activate NFkB in T-cells without interference from other inducers. It seems as if oxidation is important for the phosphorylation and degradation of the IkB inhibitor while the reduced state is essential for NFkB DNA binding.

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