Grieco Three Component Reaction

Diels-Alder-type reactions of imines with dienes (Aza Diels-Alder reactions) offer a useful means of preparing nitrogen-containing, six-membered heterocycles 31,32 , Since the imine can be formed from an aldehyde and an amine component, the overall reaction can be performed as a three-component reaction (dubbed the Grieco three-component reaction). Initially, the reaction was performed under Mannich-like conditions. The performance of the reaction could be improved significantly by using...

Info

8.13.1.4 Aldehyde to alcohol arom. aldehyde to ArCH2OH, NaAl(CH30CH2CH20)2H2 339 aldehyde to RCH2OH, NaBH sonication, with lactonisation 125 ArCOCH2R to ArC(OH)HCH2R, NaBH4 31,128 ArCOMe to ArCH(OH)Me, NaBH4 NaHC03 485 steroidal ketone to steroidal alcohol, NaBH4 or KBH4 486 PG-ketone to PG-alcohol, L-Selectride 111 R'CH2COCHR2 to R'CH2C(OH)HCHR2, Zn(BH4)2 123 8.13.1.6 Ketone to alkane ArCOCH2R to Ar(CH2)2R, LiAlH4 AlCl3 273 8.13.1.7 Thioester to aldehyde DIBAH 375 8.13.1.8 Thioester to thiol...

Electrophilic aromatic substitutions

Sb 1-hydroxyimidazole, ortho-lithiation with nBuLi, then QiCle 327 poly(p-hydroxystyrene)resin + Br2 NBu3 328 PS DVB + Br2 Tl(OAc)3, T1C13 or FeCl3 306 sb 1-hydroxyimidazole, ortho-lithiation with nBuLi, then CBr4 327 conversion of Ar-triazenes to Arl, Mel 202 sb tyrosine derivative + IPy2 BF4 330 8.4.2 Formation and reactions of metalated aromatic compounds 8.4.2.2 Addition to carbonyl compounds PS DVB-Br + nBuLi, then ethylene oxide PS DVB + BuLi TMEDA, then fluorenone 210 PS DVB-Br + nBuLi,...

Nucleophilic aliphatic substitution reactions

+ propargyl bromide, Cs2C03 DMF sb 2 amine + allyl or benzyl bromide, DMF + allyl bromide, Schwesinger base dioxane + benzyl bromide, DBU DMSO + benzyl bromide, DIEA DMF acetone + benzyl chloride, NEt3 sb 2 or 3 amine + alkyl halide, DMF sb 3 amine + allyl or benzyl bromide, DMF + alkyl halide, DMF sb ArNHR + benzyl bromide, DIEA DMF proton sponge DMSO sb indole + alkyl halide, NaH DMF sb tetrahydroisoquinoline + alkyl halide (Br or I), DMF sb xanthine + alkyl halide, NEt3 sb pyridine +...

Equipment for High Throughput Evaporation

For high-throughput evaporation, vacuum centrifuges are currently the devices which are in most widespread use. Recently, equipment using orbital shaking as an alternative has come to the fore. Key issues in both cases are efficient heat transfer to the samples to achieve good evaporation performance, and resistance against the chemicals usually encountered in organic synthesis. To address the first issue, the current centrifuge models manufactured by Savant, Christ and Genevac use IR-lamps...

Multicomponent reactions

Rink amine resin + ArCOOH RCHO RNC, MeOH CHCl, 390 + RCOOH RCHO RNC, MeOH DCM 391 + RCOOH RCOMe RNC 392 + benzoic acid RCHO RNC 393 + RCOOH RCHOAVeinreb amide isonitrile, MeOH DCM 347 sb amine + RCOOH RCHO PhNC or 2-pyNC, MeOH CHClj py 394 + RCOOH RCHO (either one a C-glycoside) RNC, sb amino acid ester + RCOOH RCHO RNC, MeOH 396 sb pyrimidine carboxylic acid + RNH2 RCHO RNC, dioxane MeOH 275 from sb RNC + ArCOCHO RNH2 RCOOH 397 5- and 6-membered lactams from sb RNC + sb ArNC + RCHO RNH2 RCOOH,...

Rs 232

septum covers or self-closing flaps for rvs available temperature time programs possible inert atmosphere in rv possible comes with reflux option built-in timer can turn heating on off at specified time built-in timer can turn heating on off at specified time STEM RS heat stir STEM chill stir glass vials or tubes held glass vials or tubes held glass tubes vials 16,20 glass tubes vials 16,20 glass vials tubes 16 mm in aluminum block in aluminum 12 24 x 150 mm or 24 10 or 18 ml 24 16 X 100 mm or...

Tfa

R2CHO, CH30 3HC O V I.BocHN COOH Scheme 9. Synthesis of diketopiperazines. Cyclative cleavage The resin 35 200 mg was shaken in toluene ortoluene ethanol 1 1 2 mL in the presence of 1 acetic acid or 4 triethylamine at room temperature for several hours 8-12 h for acidic conditions, 2-5 h for basic conditions .The resin was washed several times with ethanol, the combined filtrates were concentrated to give 36 16 . In a similar strategy, a-hydroxy acids were bound to substituted amino...