B

Furthermore, the reaction proceeded under very mild and neutral conditions. Hence, the concept was found to be very extremely versatile. For the release of the compounds after ring closure metathesis on the support there exist in principle two alternatives, as outlined in Scheme 36 [78],

The strategy outlined in concept A leads to a release of the cyclized product. At the same time, the Ru-complex is immobilized on the support. Thus, ethylene or octene were added to re-liberate the Ru-complex in a metathesis reaction from the support. The strategy was successfully applied to the synthesis of a seven-membered lactame [79] (Scheme 37).

BzCL ,OH

Was this article helpful?

0 0

Post a comment