Basf Ag

67056 Ludwigshafen

Germany

Prof. Dr. Hendrik Timmerman Faculty of Chemistry Dept. of Pharmacochemistry Free University of Amsterdam De Boelelaan 1083 1081 HV Amsterdam The Netherlands

Volume Editors: Prof. Dr. Willi Bannwarth

Department of Organic Chemistry and Biochemistry

University of Freiburg

Albertstraße 21

79104 Freiburg

Germany

Dr. Eduard Felder

Dept. of Chemistry, Oncology

Pharmacia & Upjohn S.p.A.

Viale Pasteur 10

20014 Nerviano

Italy

This book was carefully produced. Nevertheless, authors, editors and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

1st Edition 2000 1st Reprint 2002

Library of Congress Card No. applied for.

British Library Cataloguing-in-Publication Data: A catalogue record for this book is available from the British Library.

Die Deutsche Bibliothek - CIP Cataloguing-in-Publication-Data A catalogue record for this publication is available from Die Deutsche Bibliothek

© WILEY-VCH Verlag GmbH, D-69469 Weinheim (Federal Republic of Germany), 2000 Printed on acid-free and chlorine-free paper.

All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form - by photoprinting, microfilm, or any other means - nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.

Composition: Datascan GmbH, D-67346 Speyer Printing: Strauss Offsetdruck, D-69509 Mörlenbach

Printed in the Federal Republik of Germany.

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