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The initial product of the condensation is a 1,4-dihydropyridine 19, which can be oxidized to the corresponding pyridine derivative 20 [20]. Microwave-assisted combinatorial chemistry was recently applied to the high-throughput Hantzsch synthesis to create libraries of diverse substituted pyridines [21, 22]. The authors used a solvent-free approach in a 96-well plate format employing filter bottom plates. Bentonite clay was used as support and ammonium nitrate was applied as source of ammonia and oxidant [22], according to Scheme 13.

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