Info

Chemspeed Manual System

MultiSynTech SMS

Rapp Polymere APOS 1200

Reaction vessels Material/shape

Number/volume glass reactors with frit

128/5 ml, 128/13 ml, 64/27 ml, 32/75 ml, 32/100 ml, 16/130 ml

Teflon block holding polypropylene or glass syringes with frit 40/10 ml, 60/5 ml, 96/2 ml glass tubes with frit 12/3 ml wv

Agitation

Temperature range

Inert atmosphere in rv

Reflux capability

Integration with robotic equipment

Special features/ comments orbital shaking

-70 to + 150°C/up to 8 different zones, external chiller(s) required

• fully enclosed

• reagent/solvent addition under agitation possible

• parallel evaporation on the instrument

• liquid-liquid extraction tool

• parallel filtration (vessel to vessel)

• push-button or PC control

• this is an upgradable "light" version of the fully automated Chemspeed ASW 2000 (see Table 6)

magnetic lévitation stirring

• cleavage from support on the instrument, collection of products in custom block

• reagent/solvent addition under agitation possible

• this is a "light" version of the fully automated SYROII (see Table 6)

• temperature/time programs possible

• automated version available (see Table 6)

Figure 4. The modular manual synthesizer APOS 1200 (Rapp Polymere) accommodates an unlimited number of reaction units (each containing 12 rvs). An automated version is also available.

Figure 5. Chemspeed's Manual Synthesis Workstation offers special features like vessel-to-vessel filtration and parallel evaporation. It can be upgraded to a fully automated system.

ert atmosphere for all reaction vessels simultaneously. This feature is available for, or is already incorporated into, some standard reaction blocks and manual synthesizers, in particular those with built-in cooling devices for reactions under real reflux conditions (see Tables 3 and 4; Fig. 5).

6.2.3 Semiautomated Systems

These robots perform wash procedures in an automated fashion, while reagents have to be added manually. Generally, three to six online solvents are available. To accelerate wash cycles some instruments use multichannel pipettes or solvent delivery heads. For details, see Table 5.

Figure 6. Semi-automated synthesizers QUEST 210SLN (Argonaut) and LabTech (Advanced ChemTech)

Table 5. Semiautomated synthesizers

Advanced ChemTech LabTech V

Advanced ChemTech Vanguard

Advanced ChemTech ReacTech

Argonaut Trident Workstation

Reaction vessels Material/shape

Number/volume

Agitation

Temperature range

Teflon block with cavities (solid phase version with fritted cavities) 96/3.5 ml, 40/9 ml, 16/15 ml, 8/30 ml (solid phase) or 96/6 ml, 40/ 14.5 ml (solution phase)

orbital shaking -70 to 150 °C

Teflon block, cavities with frits

40/6 ml wv, 96/2 ml wv, 384/0.5 ml wv orbital shaking -70 to 150°C

Teflon block, cavities with frits

40/8 ml orbital shaking -70 to 150 °C

round bottom glass vessels

48/5 or 10 ml orbital shaking -40 to 150°C

Inert atmosphere in rv

Reflux capability

Online solvents

Special features/ comments

up to 6

• rvs septum-covered

• multichannel (up to 8) pipette for solvent delivery available

• cooling with cold nitrogen generated from liquid nitrogen up to 6

• reactive gas chemistry possible (rv can be pressurized up to 150 psi)

• multichannel pipette for solvent delivery

• rvs septum-covered

• 40 channel solvent delivery head

• cooling with cold nitrogen generated from liquid nitrogen

sealed rv septumless rvs with Teflon valve cap top filtration this is a "light" version of the fully automated Trident (see Table 6)

Argonaut Quest 205

Argonaut Quest 210 ASW/SLN

MultiSynTech SAS

Spyder

Was this article helpful?

0 0

Post a comment