The alternative attachment of the aldehyde component led to much lower yields in the Mannich reaction on solid support. An aminomethylation on an indole moiety linked to a solid support was also reported .
An extension of the application of the Mannich reaction with acetylides was achieved by combining it with a Sonogashira coupling , The involvement of the Sonogashira reaction prior to the Mannich reaction greatly enhances the number of potential acetylenes available. The pertinent reaction sequence is outlined in Scheme 18.
The yield and the purity of the desired compounds 31 were reported to be excellent.
Was this article helpful?