Aqueous work-up is a well-known purification method and is used extensively in traditional organic chemistry. The principle of this method is to use an aqueous- and an organic liquid phase, which are nonmiscible. Each particular substance has its partition coefficient between the two phases, and so it is possible to separate substances. For the generation of combinatorial libraries of individual compounds this purification principle was first used by Boger et al. [1,2].
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