O

hydantoins (ctd)

+ NaOMe/THF/MeOH

O R1

+ neat isopropylamine, w.c.s. + neat diisopropylamine, w.c.s.

+ neat diisopropylamine, w.c.s.

from other precursors

R o Ph from N-ureido-proline deritative + DIEA/DMF, 100° C, w.c.s. [203]

from sb N-carbamoyl a-amino acid amide + NEt3/MeOH,

from sb N-phenylcarbamoyl dipeptide + DIEA or DBU/DMF BocHN.

H JL

Pol"

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