Scheme 20

A variant of the THP-linker in which the THP-unit was attached via an ester function onto the solid support was applied to the synthesis of biphenyl tetrazole derivatives 43, as outlined in Scheme 21 [39]. A bromophenyl tetrazole was attached to polymer-bound dihydropyrane to yield 42. This step was followed by Suzuki coupling and acid-catalyzed release from the support to yield the desired compounds 43.


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