1

R' o via 1,3-dipolar cycloaddition

fV^o

via intramolecular 1,3-dipolar cycloaddition

via Ugi reaction

RkyN-

HO R3

from N-ArCH2CO-N-alkylamino ester + NaOEt, w.c.s.

tetramic acids (ctd) r3 o indoles and related heterocycles

HO R2

from N-RCH2CO-N-alkylamino ester + Bu4NOH, w.c.s. [516]

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