1

Wang

Wang

2-Chlorotrityl-

Ester

Ester

Amide

Ester

2-Chlorotrityl-

were modified in such a way that a linkage is introduced for the attachment of the group to the support material.

3.1.2.2.1 Linkers Based on Benzyloxycarbonyl (Z)

In order to allow attachment of an amine to a hydroxymethyl-modified support, the latter was reacted with carbonyl diimidazole (CDI) to create the activated support 1. Polymer-bound amine 2 was obtained by treatment of 1 with HNRiR2. After combinatorial synthesis, the modified amine 3 was released under acidic conditions (TFA) (Scheme 1) [12].

R3 1. Comb. Chemistry

R3 1. Comb. Chemistry

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