B

Figure 6. Effects of i.p. administration of IPS on free cortieosterone (A), body temperature (B). hippocampal extracellular levels of 5-HT (C), and behavioural activity (13) in long-term i.e.v. vehicle- and i.e.v. CRH-infused rats. In Figure A, * and + indicate Ihe first time point of statistical significance (as compared to i.p. salinc-injcctcd animals: not shown here) for i.e.v. vehicle- and CRH-infused rats, respectively (Student's t tost). In Figures B and C, * indicates the time period during which data from long-term i.e. v. vehiele- and CRH-treated animals differ significantly (MANOVA with repeated measures). In Figure D, ^indicates a significant difference between vehicle- and CRH-infused animals (Student's t test). The time point of injection is indicated by the arrow. The shaded area in Figure B represents the dark period of the diurnal cycle. Data taken from Linthorst et al., 1997 with permission of the Journal of Neuroscienee.

Figure 6. Effects of i.p. administration of IPS on free cortieosterone (A), body temperature (B). hippocampal extracellular levels of 5-HT (C), and behavioural activity (13) in long-term i.e.v. vehicle- and i.e.v. CRH-infused rats. In Figure A, * and + indicate Ihe first time point of statistical significance (as compared to i.p. salinc-injcctcd animals: not shown here) for i.e.v. vehicle- and CRH-infused rats, respectively (Student's t tost). In Figures B and C, * indicates the time period during which data from long-term i.e. v. vehiele- and CRH-treated animals differ significantly (MANOVA with repeated measures). In Figure D, ^indicates a significant difference between vehicle- and CRH-infused animals (Student's t test). The time point of injection is indicated by the arrow. The shaded area in Figure B represents the dark period of the diurnal cycle. Data taken from Linthorst et al., 1997 with permission of the Journal of Neuroscienee.

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