Info

Haptoglobin

White Blood Cells

Figure 2. Blond levels of seromucoids. corticosteroid binding globulin, haptoglobin, ant! while blood cells 24hr after inescapable shock (IS) or home cage control (HCC) treatment. Panel A depicts seromucoids. Panel B depicts corticosteroid binding globulin. Panel C depicts haptoglobin, and Panel D depicts while blood cell count.

Haptoglobin

White Blood Cells

Figure 2. Blond levels of seromucoids. corticosteroid binding globulin, haptoglobin, ant! while blood cells 24hr after inescapable shock (IS) or home cage control (HCC) treatment. Panel A depicts seromucoids. Panel B depicts corticosteroid binding globulin. Panel C depicts haptoglobin, and Panel D depicts while blood cell count.

Hours after IS (10.0 x 10*6 spleen cells)

Figure 3, Nitrite accumulation in spleen cells taken immediately, 48 hr, or 96 hi after inescapable shock (IS) or home cage control (HCC) treatment-

received increasing attention in this regard because of its adaptive role in inhibiting microbial growth. Fig. 3 shows nitrite levels (the stable end-product of NO) measured in culture from stimulated spleen cells taken at various times after IS or control treatment. Clearly, cells taken from rats that had received IS produce enhanced levels of NO ex vivo, and This effect is both delayed, requiring a number of hours after IS to occur, and persistent over days after IS. The active cells producing this NO are likely to be macrophages (Fleshlier, Nguyen, Cotter, Watkins, & Maier, 1998). Similar results have been obtained for IL-1p production in culture, although we have not yet completed a full timecourse. IS cannot "directly bind1' to macrophages or other peripheral cells as can pathogens. LPS, etc. Therefore, the conclusion is that IS leads to an outflow product from brain that alters macrophage activity. rI"he identity of this product or process is not known. However, again, the similarity between the effects of IL-1 injection into the brain and IS are striking. ICV IL-1 also produces increases in acute phase proteins, white blood cell counts, and basal corticosteroid levels, and reduces levels of CBG.

Defeat Depression

Defeat Depression

Learning About How To Defeat Depression Can Have Amazing Benefits For Your Life And Success! Discover ways to cope with depression and melancholic tendencies! Depression and anxiety particularly have become so prevalent that it’s exceedingly common for individuals to be taking medication for one or even both of these mood disorders.

Get My Free Ebook


Post a comment