Nitric Oxide and Endothelial Dysfunction

Several groups have shown that insulin-resistant subjects have a reduced insulin-stimulated increase in leg blood flow; the changes in peripheral blood flow were closely associated with the degree of insulin resistance (22,32-35). This endothelial dysfunction is demonstrated not only in patients with type 2 diabetes but also in nondiabetic subjects, such as obese adolescents or first-degree relatives of patients with type 2 diabetes (33,35,36).

It seems that peripheral blood flow is augmented via an insulin-mediated NO-dependent process (Fig. 3), and inhibition of NO formation prevents the

insulin-induced increase in blood flow (37). Thus, NO could indirectly affect insulin sensitivity as it increases peripheral blood flow and subsequent substrate delivery to the skeletal muscle. However, there is still a debate about the clinical relevance of these findings.

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment