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Figure 6 Schematic diagram of the proposed a-lipoic acid signaling mechanism, a-Lipoic acid uses components of the insulin signaling pathway in its ability to stimulate glucose uptake via the rapid translocation of GLUT1 and GLUT4 to the plasma membrane. In L6 myotubes, it has been shown that lipoic acid activates phosphatidylinositol 3-kinase (PI3K) and Akt in a wortmannin-sensitive fashion. These results indicate that lipoic acid uses components of the insulin signal transduction cascade in its ability to increase glucose uptake into insulin-responsive cells in culture.

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