ATocopherol Is A Specific Inhibitor Of Cell Proliferation

a-Tocopherol, at concentrations between 10 and 50 ¡iM, was shown to inhibit rat A7r5 smc proliferation (Fig. 1), whereas (^-tocopherol appeared ineffective (48). When a-tocopherol and p-tocopherol were added together, no inhibition of cell proliferation was seen. Both compounds were transported equally in c o c o

10 20 30 40 d-a-Tocopherol concentration, nM

Figure 1 Inhibition of SMC proliferation. Quiescent cells were restimulated with FCS in the presence of the indicated concentrations of a-tocopherol. For DNA synthesis determination, [3H]thimydine was given to the cells in the S-phase. The control represents 84,332 ±5150 cpm.

cells and did not compete with each other for uptake (48). The oxidized product of a-tocopherol, a-tocopheryl quinone, and several other water- and lipid-soluble antioxidants were not inhibitory, indicating that the effects of a-tocopherol were not related to its antioxidant properties (48).

Inhibitory effects of a-tocopherol were also observed in primary human aortic smc, Balb/3T3 mouse fibroblasts, and NB-2a mouse neuroblastoma but not in Chinese hamster ovary (CHO), Saos-2 human osteosarcoma cells, or P388 mouse macrophages.

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