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AGE (years)

Figure 3 Age-dependent increase in (A) MetSO and (B) ¿»-tyrosine in human skin collagen from diabetic and nondiabetic subjects. Despite significant differences in the absolute concentrations of these biomarkers, there is a strong correlation (C) between levels of these primary oxidation products in skin collagen. (From Ref. 20.)

o-Tyr (nmol/mol Phe)

Figure 3 Age-dependent increase in (A) MetSO and (B) ¿»-tyrosine in human skin collagen from diabetic and nondiabetic subjects. Despite significant differences in the absolute concentrations of these biomarkers, there is a strong correlation (C) between levels of these primary oxidation products in skin collagen. (From Ref. 20.)

served in diabetic serum (32,33), suggesting a more generalized increase in carbonyl stress (11) in diabetes.

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