Examples Of Infusion Drugs That Photodegrade

Ketoprofen Decarboxylation

Polyunsaturated fatty acids, commonly used in drug formulations, are particularly susceptible to oxidation, and care must be exercised to minimize degradation in formulations containing high concentrations of, for example, vegetable oils (31). The oxidation of phenothiazines to the sulfoxide involves two single-electron transfer reactions involving a radical cation intermediate the sulfoxide is subsequently formed by reaction of the cation with water (32). The ether group in drugs such as...

Anatomical And Physiological Considerations Of The Gastrointestinal Tract

Villi Diagram Black And White

The GIT is a highly specialized region of the body whose primary functions involve the processes of secretion, digestion, and absorption. Since all nutrients needed by the body, with the exception of oxygen, must first be ingested orally, then processed by the GIT, and then made available for absorption into the bloodstream, the GIT represents a significant barrier and interface with the environment. The primary defense mechanisms employed by the gut to rid it of noxious or irritating materials...

Effects of Organ Size Blood Flow and Partition Coefficient on Distribution

Partition Coefficient Drugs

A particular organ in the body may act as a site of distribution or as a site of both distribution and elimination. The relative importance of the various organs as storage or aExcerpted from Oie and Benet, Modern Pharmaceutics, 4th Edition. Figure 1 Process of drug absorption and distribution following administration of a single dose. The drug reaches the desired site of action either directly or via the general circulation. The drug may also reach other tissue sites or may be eliminated by...