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Thus, the biologic half-life of a drug can increase dramatically when the organs of elimination are diseased or nonfunctional; it may increase to varying degrees if these organs are partially impaired.

At the present time, no simple relationship exists between clinical measurements of liver function and the value of km. Fortunately, kidney function can be measured quantitatively using standard clinical tests, and it is directly related to ke for a number of drugs. Great success has been achieved in using kidney clearance measurements to predict the biologic half-lives of a number of drugs.

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