Saturation Solubility of the Drug

The next term in equation (4) that can be manipulated is cs, the saturation solubility of the drug. This variable can be influenced by both patient and pharmaceutical variables. The patient variables include the changes in pH as well as the amounts and types of secretions along the GIT. Additionally, both the physical and chemical properties of a drug molecule can be modified to increase or decrease its saturation solubility.

Salt Form of the Drug

Table 2 lists the large variety of salt forms of drugs approved by the FDA in the period 1995 to 2005, as collated by Serajuddin (27). Salt forms can be chosen to optimize the

Table 2 Salt Forms of NCEs Approved by the FDA from 1995 to 2006

Salts of basic drugs

Total number

Hydrochloride

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