Significance of ke and km in Patients with Kidney or Liver Disease

In the foregoing example, the drug was administered to a healthy subject who had normal kidney and liver function. The estimated biologic half-life in this person was 1.2 hours. If the same drug were administered to a person with no kidney function but with a normal liver, it would be impossible for this individual to excrete unchanged drug. They would, however, be able to metabolize the drug at the same rate as a normal individual. The net result would be that the overall kel would be reduced to the value of km, and the biologic half-life would increase to

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