Vdcp

'Cpdt

where At/Vd is the amount of drug absorbed up to time t divided by the volume of distribution, C'p is plasma (serum or blood) concentration at time t, and J0 Cp dt is the area under the plasma (serum or blood) concentration versus time curve up to time t (see sect. "Area under the Plasma Concentration versus Time Curve"). An equation similar to equation or o o

(40) can be derived by integration from t = 0 to t = 1. Since Cp = 0 at t = 1, the equation becomes

Cpdt

where Amax is the total amount of drug absorbed from the dosage form divided by the i volume of distribution; and J Cpdt is the area under the entire plasma (serum or blood)

0 0

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