Dosage Factors Influencing Absorption

Dosage form factors include excipients and dosage forms, which may affect drug absorption (Rouge et al., 1996; Badawy Sherif et al., 2006). The disintegrants can enhance the dissolution rate of the drugs and increase absorption. Surfactants such as Tween-80 may increase drug solubility of poorly soluble drugs, and increase drug absorption through enhancement of the drug permeability. The coating of enteric-coated tablets such as cellulose acetate can only be dissolved in the intestine at high pH (> 5), which protects the drug from degradation in gastric condition and against drug stimulation of gastric mucosa. in such cases, the controlled release dosage form will have a completely different absorption profile as compared with immediate release dosage forms.

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