Material Properties of Mucoadhesives

Mucoadhesives are characterized by material properties that contribute to good adhesiveness according to one or more theories of mucoadhesion. Such material properties are the ability to swell, their ability to form molecular bonds with the mucus layer, and their spatial conformation due to the entanglement of chains. The creation of molecular bonds and the entanglement of chains result in changes in their rheological behavior of the mucoadhesive polymers. The rheological properties of mucoadhesives can therefore be used as an indication of the extent of molecular bonding and spatial conformation. The cohesiveness of mucoadhesives contributes indirectly to their adhesive ability, since it deals with the internal strength of the mucoadhesive. Dodou et al. (2005) have discussed and revisited these properties of mucoadhesive polymer:

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