Aguiar A.J., Krc J., Kindel A.W., and Samyn J.C., 1967. Effect of polymorphism on the absorption of chloramphenicol from chloramphenicol palmitate. J. Pharm. Sci., 56, 847-853.
Amidon G.L., Lennernas H., Shah V.P., and Crison J.R., 1995. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res., 12(3), 413-420. Avdeef A., 2001. High throughput measurements of solubility profiles. In Pharmaco-kinetic Optimization in Drug Research; Biological, Physiochemical, and Computational Strategies. Edited by Testa B., et al., Verlag Helvitica Chimica Acta., Zurich, 305-326.
Bevan C. and Lloyd R.S., 2000. A high-throughput screening method for the determination of aqueous drug solubility using laser nepholometry in microtiter plates. Anal. Chem., 72, 1781-1787.
Borchardt R.T., Kerns E.H., Hageman M.J., Thakker D.R., and Stevens J.L., 2006. Optimizing the "Drug-Like" Properties of Leads in Drug Discovery. AAPS Press, Arlington, VA.
Connors K.A., Amidon G.L., and Stella V.J., 1986. Chemical Stability of Pharmaceuticals. A Handbook for Pharmacists. 2nd Edition. Wiley, New York.
Curatolo W., 1998. Physicochemical properties of oral drug candidates in the discovery and exploratory development settings. Pharm. Sci. Technol. Today, 1, 387-393.
Dressman J.B., 2000. Dissolution testing of immediate-release products and its application to forcasting in vivo performance. In Oral Drug Absorption, Prediction and Assessment. Edited by Dressman J.B. and Lennernas H., Marcel Dekker, New York, 155-181.
Duddu S., Vakilynejad M., Jamili F., and Grant D., 1993. Stereoselective dissolution of propranolol hydrochloride from hydroxypropyl methylcellulose matrices. Pharm. Res., 10, 1648-1653.
Glomme A., Marz J., and Dressman J.B., 2004. Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities. J. Pharm. Sci., 94, 1-16.
Gomez-Orellana I., 2005. Strategies to improve oral drug bioavailability. Expert Opin. Drug Deliv., 2(3), 419-433.
Grant D.J.W. and Highuchi T., 1990. Solubility Behavior of Organic Compounds. Wiley, New York.
Gu C.H., Rao D., Gandhi R.B., Hilden J., and Raghavan K., 2005. Using a novel multicom-partment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility. J. Pharm. Sci., 94, 199-208.
Haleblian J. and McCrone W., 1969. Pharmaceutical applications of polymorphism. J Pharm. Sci., 58, 911-929.
Hancock B.C. and Parks M., 2000. What is the true solubility advantage for amorphous pharmaceuticals? Pharm. Res., 17(4), 397-404.
Hancock B.C. and Zografi G., 1997. Characteristics and significance of the amorphous stage in pharmaceutical systems. J. Pharm. Sci., 86, 1-12.
Horter D. and Dressman J.B., 1997. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Deliv. Rev., 25, 3-14.
Huang L.F. and Tong W.Q., 2004. Impact of solid state properties on developability assessment of drug candidates. Adv. Drug Deliv. Rev., 56, 321-334.
Huuskonen J., Salo M., and Taskinen J., 1998. Aqueous solubility prediction of drugs based on molecular topology and neural network modeling. J. Chem. Inf. Comput. Sci., 38, 450-456.
Jain N. and Yalkowsky S.H., 2000. Estimation of the aqueous solubility I: application to organic non-electrolytes. J. Pharm. Sci., 90, 234-252.
Jamali F., 1992. Stereochemistry and bioequivalance. J. Clin. Pharmacol., 32, 930-934.
Johnson K.C. and Swindell A.C., 1996. Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm. Res., 13, 1795-1798.
Kerns E.H., 2001. High throughput physicochemical profiling for drug discovery. J. Pharm. Sci., 90(11), 1838-1858.
Kerns E.H. and Di L., 2003. Pharmaceutical profiling in drug discovery. Drug Discov. Today, 8(7), 316-323.
Kostewicz E.S., Wunderlich M., Brauns U., Becker R., Bock T., and Dressman J.B., 2004. Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine. J. Pharm. Pharmacol., 56, 43-51.
Leeson P.D. and Davis A.M., 2004. Time-related differences in the physical properties of oral drugs. J. Med. Chem., 47, 6338-6348.
Li S.F., Wong S.M., Sethia S., Almoazen H., Joshi Y., and Serajuddin A.T.M., 2005. Investigation of solubility and dissolution of a free base and two different salt forms as a function of pH. Pharm. Res., 22(4), 628-635.
Lipinski C.A., Lombardo F., Dominy B.W., and Feeney P.J., 1997. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 23, 3-25.
Lobenberg R., Amidon G.L., and Vieira M., 2000. Solubility as a limiting factor to drug absorption. In Oral Drug Absorption, Prediciton and Assessment. Edited by Dressman J.B and Lennernas H., Marcel Dekker, New York, 137-153.
Macheras P., Reppas C., and Dressman J.B., 1995. Biopharmaceutics of Orally Administered Drugs. Ellis Horwood Limited.
Nystrom C., 1998. Dissolution properties of poorly soluble drugs: theoretical background and possibilities to improve the dissolution behavior. In Emulsions and Nalosuspensions for the Formulation of Poorly Soluble Drugs. Edited by Muller R.H., Benita S., and Bohm B., Medpharm Scientific Publishers, Stuttgart.
Pudipeddi M., Serajuddin A.T.M., Grant D.J.W., and Stahl P.H., 2002. Solubility and dissolution of weak acids, bases and salts. In Handbook of Pharmaceutical Salts, Properties, Selection, and Use. Edited by Stahl P.H. and Wermuth C.G., Verlag Helvetica Chimica Acta, Zurich, 19-39.
Rabinow B.E., 2004. Nanosuspensions in drug delivery. Nature Rev., 3(9), 785-796.
Ran Y., Jain N., and Yalkowsky S.H., 2001. Prediction of aqueous solubility of organic compounds by the general solubility equition (GSE). J. Chem. Inf. Comput. Sci., 41, 1280-1217.
Shanker R., 2005. Current concepts in the science of solid dispersions. Second Annual Simonelli Conference in Pharmaceutical Sciences. Long Island University.
Taskinen J. and Yliruusi J., 2003. Prediction of physicochemical properties based on neutal network modelling. Adv. Drug Deliv. Rev., 55, 1163-1183.
Tong W.Q., 2000. Preformulation aspects of insoluble compounds. In Water Insoluble Drug Formulation. Edited by Liu R., Interpharm Press, Denver, Colorado, 65-95.
Tong W.Q. and Whitesell G., 1998. In situ salt screening - a useful technique for discovery support and preformulation studies. Pharm. Dev. Tech., 3(2), 215-213.
Vasanthavada M., Tong W.Q., Joshi Y., and Kislalioglu M.S., 2004. Phase behavior of amorphous molecular dispersions I: determination of the degree and mechanism of solid solubility. Pharm. Res., 21(9), 1589-1597.
Vasanthavada M., Tong W.Q., Joshi Y., and Kislalioglu M.S., 2005. Phase behavior of amorphous molecular dispersions II: role of hydrogen bonding in solid solubility and phase separation kinetics. Pharm. Res., 22(3), 440-448.
Veber D.F., Johnson S.R., Cheng H.Y., Smith B.R., Ward K.W., and Kopple K.D., 2002. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem., 45, 2615-2623.
Vieth M., Siegel M.G., Higgs R.E., Watson I.A., Robertson D.H., Savin K.A., Durst G.L., and Hipskind P.A., 2004. Characteristic physical properties and structural fragments of marketed oral drugs. J. Med. Chem., 47, 224-232.
Waterbeemd H., Smith D.A., and Jones B.C., 2001. Lipophilicity in PK design: methyl, ethyl, futile. J. Comput. Aided Mol. Des., 15(3), 273-286.
Wenlock M.C., Austin R.P., Barton P., Davis A.M., and Lesson P., 2003. A comparison of physiochemical property profiles of development and marketed oral drugs. J. Med. Chem., 46, 1250-1256.
Winnike R., 2005. Solubility assessment in pharmaceutical development, practical considerations for solubility profiling and solubilization techniques. AAPS Short Course on Fundamentals of Preformulation in Pharmaceutical Product Development. Nashville, TN, Nov. 5, 2005.
Yalkowsky S.H., 1999. Solubility and Solubilization in Aqueous Media. American Chemical Society, Washington D.C.
Yalkowsky S.H. and Valvani S.C., 1980. Solubility and partitioning I: solubility of non-electrolytes in water. J. Pharm. Sci., 69, 912-922.
Was this article helpful?
Stop Your Scalp From Snowing! Finally... A Real Cure for Dandruff! No medication! No weird cures! No messy creams, smelly solutions or strange diets! Are you sick to death of being sold products that could make the problem worse? Are you sick of the shampoos and conditioners that make your head smell like sulphur? If so then try a permanent revolutionary treatment for dandruff!