Spatial conformation

The interpenetration rate of the mucus-mucoadhesive chains depends on the diffusion coefficient and the chemical potential gradient of the interacting macromole-cules (Huang et al., 2000). The flexibility and mobility of the mucoadhesive chains as well as the expanded form of the mucoadhesive network control the effective chain length which can penetrate into the mucus (Lee et al., 2000; Peppas and Huang, 2004). In this way spatial conformation is critical for the interpenetration of mucus-mucoadhesive chains.

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