Three Primary Factors Influence Drug Absorption

Permeability, solubility, and dissolution are the three primary factors that influence drug absorption (Narawane and Lee, 1994; Lennernas, 1998; Zhou et al., 2005). Permeability reflects the physiological properties of membrane to the solutes. Fraction of drug absorbed is determined by the drug permeability through intestinal wall. Solubility is one of the physicochemical properties of drug molecules to affect drug absorption. The drug molecules have to be dissolved in solution in order for absorption to occur in the intestinal tract. Dissolution is the dosage form variable to determine the rate and extent of drug dissolved in solution.

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