Microdialysis has been used to estimate concentrations of unbound drug present in the extracellular fluids in various tissues or organs or in blood in vivo (Fig. 7.4). For microdialysis sampling, a dialysis capillary with a typical outer diameter of 500 ^m is implanted in tissues or within blood vessels. and the capillars is then

Perfusate (physiological buffer)

Outlet flow (sample collectic

Outlet flow (sample collectic

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