Microdialysis

Microdialysis has been used to estimate concentrations of unbound drug present in the extracellular fluids in various tissues or organs or in blood in vivo (Fig. 7.4). For microdialysis sampling, a dialysis capillary with a typical outer diameter of 500 ^m is implanted in tissues or within blood vessels. and the capillars is then

Perfusate (physiological buffer)

Outlet flow (sample collectic

Outlet flow (sample collectic

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