Conclusion

The design of self-emulsifying lipid formulations of poorly water-soluble drugs has been described and examples, where these formulations approaches were successfully applied to challenging drug molecules associated with poor bioavailability. The bioavailability of a poorly soluble drug administered in a lipid solution, SEDDS or SMEDDS formulation is dependent upon several factors including:

■ digestability of the lipid and the type of lipid vehicle used in which the drug is solubilized,

■ droplet size of the formed emulsion that is produced following exposure to GI fluids,

■ release rate of the drug from the emulsified oil droplets, which is determined by the relative droplet polarity and surface area.

Was this article helpful?

0 0

Post a comment