Lipidbased Hard Gelatin Capsule Formulation Development

As typical fill volumes for HGC fall in the range of 0.2 to 0.9 mL, the formula-tor may initially target a maximum fill volume of 0.5 to 0.7 mL for estimating the required solubility of the drug in the excipient matrix intended for the prototype formulations (Table 1).

Table 1 Capsule Size and Approximate Volumes (Licaps)

Capsule size

Approximate body volume (cc)


Was this article helpful?

0 0

Post a comment