Lipid Polysorbate Mixtures

Polysorbates have proven useful in preparing solid dispersion formulations of poorly water-soluble drugs in combination with excipients other than PEGs. One interesting formulation approach was reported by Attama et al. (47), who described the preparation of homogeneous dispersions of up to 30% w/w of diclofenac in molten mixtures of polysorbate 65 and goat fat (melting point 51°C). Molded tablets were prepared by allowing the molten formulation to congeal at ambient room temperature. The in vitro dissolution rate of the drug from this formulation was proportional to the surfactant concentration.

Was this article helpful?

0 0

Post a comment