Concluding Remarks

In summary, RA is a heterogeneous disease with regard to severity of the joint inflammation and other inflammatory manifestations. To prevent disease onset or progression of disease in the single patient, distinct biomarkers are needed, and only a few have yet been identified. The fact that the presence or absence of ACPAs divides the disease into two distinct entities will very likely influence future treatments and clinical trials. Clinical trials, if not already focusing on a subgroup of patients, need also to be adequately powered to allow subgrouping patients according to genetic setup, environmental exposures, and different nonsynovial inflammations in order to find biomarkers for individualized therapies. Today ^ and tomorrow^ biological therapies targeting different parts of the immune and inflammatory pathways will also increase our understanding of disease etiology and progression and help identify new drugs.

Project Management Made Easy

Project Management Made Easy

What you need to know about… Project Management Made Easy! Project management consists of more than just a large building project and can encompass small projects as well. No matter what the size of your project, you need to have some sort of project management. How you manage your project has everything to do with its outcome.

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