Conclusions Challenges And Future Opportunities

One of the most salient features of imaging science, which is relevant to both diagnostic imaging and imaging biomarkers, is that the state of the technology does not stand still. Continuous research and development for more than 30 years has produced a steady stream of new imaging technologies as well as incremental improvements that address the limitations of existing technologies. Development and implementation strategies for imaging biomarkers must account for this continuous change and attempt to balance the needs of standardization with the adoption of new innovative technologies. Like software, imaging biomarkers will probably need to be "versioned" to account for changes to the underlying technologies. However, this will also require a continuous process of development and maintenance, for which an open-source model may be the most appropriate. Moreover, with the continued introduction of new imaging technologies, in the future we might expect the translation of additional image-based biological measures to promising new imaging bio-markers. This will become increasingly feasible as innovative systems make imaging biomarker development more routine.

It seems likely that no one biomarker will be able to adequately capture all of the important aspects of a given disease process or biological response to therapy. A combination of imaging and other biomarkers may be the most effective surrogate endpoint tool for drug development. In addition to the requirements of biomarker validation and qualification, this will require that the component biomarker technologies are cost-effective as a combination.

Current collaborative efforts being led by public-private partnerships such as the FNIH and by the NIH and QIBA are starting to address many of the hurdles of imaging biomarker development and standardization. New approaches that allow contributions from all stakeholders will accelerate the work of imaging biomarker validation and qualification, and we might expect that these initiatives will soon lead to broader availability of new imaging biomarker tools for drug development.

Project Management Made Easy

Project Management Made Easy

What you need to know about… Project Management Made Easy! Project management consists of more than just a large building project and can encompass small projects as well. No matter what the size of your project, you need to have some sort of project management. How you manage your project has everything to do with its outcome.

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