Info

+ 0.79 *

75.4 +

1.60 *

"*, Mean value ± S.E.M. for 10 individual subjects significantly different from 0.98 ISI thromboplastin means at 5% level by i-test, separately by increasing ISI value for individual rabbit thromboplastins.

"*, Mean value ± S.E.M. for 10 individual subjects significantly different from 0.98 ISI thromboplastin means at 5% level by i-test, separately by increasing ISI value for individual rabbit thromboplastins.

plastin used and showed smaller maximum changes in PT values. In contrast, rat PT values were highly dependent on the source of thromboplastin, and samples tested with rabbit brain thromboplastin were markedly longer than with human recombinant thromboplastin. Rats showed this high level of thromboplastin dependence even in untreated control samples. Variability of PT in FXa inhibitor-treated human and dog plasma was similar to that observed in controls and did not change appreciably with increasing concentration of drug (Table 2). FXa inhibitor- treated rat plasma showed an approximately twofold increase in variability compared to control.

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Project Management Made Easy

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