Principles Of Target Selection

Two key guiding principles are essential in the early selection process of molecular targets:

1. Modulating the target carries the prospect of unequivocal medical benefit (efficacy) to patients beyond a standard of care.

2. Benefits can be garnered while maintaining a sufficient level of safety that can be realized within the attainable compound exposure.

Such a mission is frequently unachievable, and hence establishing an acceptable therapeutic index is the practical goal for most drug development schemes. Commonly, a therapeutic index is established by calculation of the ratio of the maximum tolerated dose (MTD) and the minimum effective dose (MED) in animal efficacy and safety studies. In this light, targets selected for drug development can be classified with respect to risk assessment based on the following categories (Figure 2):

Class A. The target is only present and contributing to the disease process. Class B. The target is present physiologically but in a nonactive form, but then is activated and contributes to the disease. Class C. The target functions physiologically but in an augmented, uncontrolled fashion that contributes to the disease. Class D. The target functions in normal states and indiscriminately in disease (e.g., no difference in target expression, functions, or distribution can be identified in disease as compared to the normal physiological state).

Project Management Made Easy

Project Management Made Easy

What you need to know about… Project Management Made Easy! Project management consists of more than just a large building project and can encompass small projects as well. No matter what the size of your project, you need to have some sort of project management. How you manage your project has everything to do with its outcome.

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