Human Plasma S

Rt (min) Rt (min) RT (min) Increasing intensity of selected ion -â–º

Chapter 5, Figure 1 Consistent peptide intensity across all samples allows the detection of differentially expressed peptide ions. Shown is a partial view of peptide ion maps (as measured by LC-MS) from the plasma of three individuals. The horizontal axis is chromatographic retention time, the vertical axis is mass-to-charge ratio (m/z), and the peptide ion intensity is denoted by the size and color of the spots. The peptide ion circled shows differential expression across patients and increases in abundance from sample 1 to sample 3.

Chapter 5, Figure 4 Global proteomics analysis on Alzheimer disease and normal patients. Multidimensional scaling of proteomics data demonstrates the separation of healthy individuals (green spheres) from Alzheimer patients (red spheres). Caprion has defined a disease axis that is used to quantify relative disease state. The axis is a line that passes through the disease and healthy centroids (yellow spheres). Each patient is then positioned on the axis according to its orthogonal intercept. Donepezil-treated Alzheimer patients (purple spheres), as a group, are shifted on the disease axis from the disease group toward the healthy group.

Multidimensional Scaling (Log Transform OFF)

n n

Project Management Made Easy

Project Management Made Easy

What you need to know about… Project Management Made Easy! Project management consists of more than just a large building project and can encompass small projects as well. No matter what the size of your project, you need to have some sort of project management. How you manage your project has everything to do with its outcome.

Get My Free Ebook

Post a comment