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Table 1 Herbal Drug Approval Rules in Different Countries (Continued) U.S.A. Since 1994, herbal medicines have been regulated under the Dietary Supplement Health and Education Act of 1994. On the basis of this law, herbal medicines are not evaluated by the FDA and, most important, these products are not intended to diagnose, treat, cure, or prevent diseases. The U.S. FDA issued its first botanical drugs approval guidelines in August 2000. The mission of the NCCAM is, in part, to conduct...

Bibliography

A flexible technology for modified release of drugs multi-layered tablets. J Control Release 2004, 7 Jul 97(3) 393-405. Abrams J. Glyceryl trinitrate (nitroglycerin) and the organic nitrates. Choosing the method of administration. Drugs 1987 Sep 34(3) 391-403. Aldridge MA, Ito MK. Colesevelam hydrochloride a novel bile acid-binding resin. Ann Pharmacother 2001 Jul-Aug 35(7-8) 898-907. Atkins PJ. Dry powder inhalers an overview. Respir Care 2005 Oct 50(10) 1304-1312...

Hfsh

Composition, 340 High-performance liquid chromatography (HPLC), 58, 107, 117, 118-119, 230 - 231, 357-358 IEX, 358 High-resolution probes cellular imaging, 14 High-throughput crystal screening solid-state properties, 207-209 High-throughput screening (HTS), 1,13, 22, 120, 151 solubility, 227 Hit-to-lead (HTL), 1 HIV protease inhibitors polymorphs, 206 Hot stage microscopy (HSM), 58, 206, 220 HPLC. See High-performance liquid chromatography HTL. See Hit-to-lead HTS. See High-throughput screening...

Characteristics Of Phytomedicines

Phytotherapeutic agents or phytomedicines are standardized herbal preparations consisting of complex mixtures of one or more plants, which are used in most countries for the management of various diseases. According to the WHO definition, herbal drugs contain as active ingredients plant parts or plant materials in the crude or processed state plus certain excipients, that is, solvents, diluents, or preservatives. Usually, the active principles responsible for their pharmacological action are...

Ii

Figure 3 m-PEGylation using N-hydroxysuccini-mide ester. linear PEG counterpart. A branched PEG reagent was used in the creation of PEGASYS (PEGylated-interferon alpha) by Roche and on aptamers. Substitution values are 95 or greater. Spectrophotometric analyses are the most common method to characterize proteins. The use of ultraviolet-visible (UV-VIS) spectroscopy is typically used for the determination of protein concentration by using either a dye-binding assay (e.g., the Bradford or Lowry...

Phytomedicines

The search for and exploitation of natural products and properties has been the mainstay of the biotechnology industries. Natural product search and discovery, however, is not synonymous with drug discovery. But, if we examine how novel natural product chemotypes along with interesting structures and biological activities continue to be reported, this becomes the mainstay of drug discovery as it has been in the therapeutic areas, such as neurodegenerative disease, cardiovascular disease, most...

Article On Amalpitta

Abt AB, Oh JY, Huntington RA, Burkhart KK. Chinese herbal medicine induced acute renal failure. Arch Intern Med 1995 155 211-212. Ackerknecht EH. Therapeutics from the Primitives to the Twentieth Century. New York Hafner Press, 1973. Adams D. Herbal tea made woman's face stop light, court told. Age Melbourne 1995, 12 Dec 7. Akamasu E. Modern Oriental Drugs. Tokyo Yishiyakusha. Akerele O. Summary of WHO guidelines for the assessment of herbal medicines. HerbalGram 1993 28 13-19. Anonymous....

Bibliography Of Drug In Pomocology

Dehydration of theophylline monohydrate powder-effects of particle size and sample weight. Int J Pharma 1994 106 33-40. Ahlneck C, Zografi G. The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state. Int J Pharm 1990 62 87-95. Ahmed S, Owen CP, James K, Patel CK, Patel M. Acid dissociation constant, a potential phys-icochemical factor in the inhibition of the enzyme estrone sulfatase ES . Bioorg Med Chem Lett 2001, 9 Apr 11...

Index

Abbott Laboratories calcitriol patent expiration, 7, 34 chemical diversity, 3 Abciximab vs. assay complexity, 147 Absorption and distribution in body, metabolism and elimination from body ADME , 120, 149 Accelerated testing drug product dissolution, 245 polymorphs, 208 Acid-base theory, 88-89 Acids pKa, 217 Activation energy, 304 Active pharmaceutical ingredients API , 59, 65,141, 322 expiry, 324 Actual reduction to practice solubility, 112 ADME. See Absorption and distribution in body,...