a Distribution phase rate constant for a 2-compart-

ment model

A y-Axis intercept for distribution phase

AUC Area under the blood/plasma concentration-time profile

S.C. Khojasteh et al., Drug Metabolism and Pharmacokinetics 1

Quick Guide, DOI 10.1007/978-1-4419-5629-3_1, © Springer Science+Business Media, LLC 2011

AUCExtravascular |
AUC following an extravascular dose (i.e., oral, |

subcutaneous, intraperitoneal) | |

AUCiv |
AUC following an intravenous dose |

b |
Terminal elimination phase rate constant for |

2-compartment model | |

B |
y-Axis intercept for terminal elimination phase |

Wn |
Concentration entering liver or organ |

Cinitial |
Initial concentration |

Cout |
Concentration exiting the liver or organ |

CL |
Clearance |

CLint |
Intrinsic metabolic clearance |

Lmax |
Highest or peak blood/plasma concentration |

Cmax(ss) |
Cmax at steady state |

E |
Extraction ratio |

F |
Bioavailability |

fu |
Unbound fraction in blood/plasma |

fuT |
Unbound fraction in tissue |

k |
First-order terminal elimination rate constant |

ki2 |
Intercompartment rate constant from central to |

peripheral compartment | |

kii |
Intercompartment rate constant from peripheral |

to central compartment | |

ka |
First-order absorption rate constant |

MRT |
Mean residence time |

Q |
Hepatic blood flow |

R |
Accumulation ratio |

T |
Tau; dosing interval |

^ 1/2 |
Half-life |

^max |
Time at which Cmax occurs |

Vb |
Nomenclature for Vd for a 2-compartment model |

Vc |
Volume of the central compartment |

Vd |
Volume of distribution |

vp |
Volume of plasma |

Vss |
Volume of distribution at steady state |

VT |
Volume of tissue |

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