Abbreviations

a Distribution phase rate constant for a 2-compart-

ment model

A y-Axis intercept for distribution phase

AUC Area under the blood/plasma concentration-time profile

S.C. Khojasteh et al., Drug Metabolism and Pharmacokinetics 1

Quick Guide, DOI 10.1007/978-1-4419-5629-3_1, © Springer Science+Business Media, LLC 2011

AUCExtravascular

AUC following an extravascular dose (i.e., oral,

subcutaneous, intraperitoneal)

AUCiv

AUC following an intravenous dose

b

Terminal elimination phase rate constant for

2-compartment model

B

y-Axis intercept for terminal elimination phase

Wn

Concentration entering liver or organ

Cinitial

Initial concentration

Cout

Concentration exiting the liver or organ

CL

Clearance

CLint

Intrinsic metabolic clearance

Lmax

Highest or peak blood/plasma concentration

Cmax(ss)

Cmax at steady state

E

Extraction ratio

F

Bioavailability

fu

Unbound fraction in blood/plasma

fuT

Unbound fraction in tissue

k

First-order terminal elimination rate constant

ki2

Intercompartment rate constant from central to

peripheral compartment

kii

Intercompartment rate constant from peripheral

to central compartment

ka

First-order absorption rate constant

MRT

Mean residence time

Q

Hepatic blood flow

R

Accumulation ratio

T

Tau; dosing interval

^ 1/2

Half-life

^max

Time at which Cmax occurs

Vb

Nomenclature for Vd for a 2-compartment model

Vc

Volume of the central compartment

Vd

Volume of distribution

vp

Volume of plasma

Vss

Volume of distribution at steady state

VT

Volume of tissue

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