Alcohol Dehydrogenases ADHs EC 1111

Subcellular location: Cytosol and blood.

Organ distribution: Widely distributed, but the highest concentration is in the liver, stomach, and brain.

Cofactor: NAD+ (Zn-containing).

Reaction: Oxidation of alcohols to aldehydes or ketones.

For alcohol oxidation, primary alcohols are preferred over secondary alcohols, most likely because of steric hindrance. In this mechanism of oxidation, a hydride (H~) is transferred to NAD+ to form NADH, and it is pro-R-specific.

Isoforms: High multiplicity. The major classes in humans are ADH1 to ADH5.

ADH is one of the major enzymes involved in ethanol metabolism and may have a protective effect against alcoholism.

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