CL is the volume of blood cleared of compound/drug per unit time. CL units are volume/time (i.e., mL/min). CLs by various organs are additive. The total body CL of a compound is a summation of the CL contributions of various organs.
CLtotalbody = CLliver + CLrenal + CLother (L2)
CL can be calculated as follows:
'1/2 where k is the first-order elimination rate constant (units of time-1)
t1/2 is the half-life (units of time)
Vd is the volume of distribution (units of volume)
Hepatic metabolism is the primary route of elimination for most compounds. A general assumption, although not always true, is that CLiiver (due to hepatic metabolism) is equal to
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